Objective:

To explore the application of gamification strategies in clinical trials, focusing on patient engagement and data collection, and assess perceptions of patients and clinical trial sites regarding its acceptance and implementation.

Key Findings:

• Twenty-four articles focused on gamification in non-gaming activities, highlighting its potential in enhancing patient engagement.
• Eighteen studies reported advantages of gamification, particularly in health outcomes and patient engagement, suggesting a positive trend.
• 62% of adult respondents were familiar with computer games and preferred gamified trial applications, indicating a readiness for innovation.
• Concerns included impacts on behavior (33%) and data privacy (26%), which need to be addressed for successful implementation.
• Site respondents preferred managing trials with gamified elements over traditional trials, suggesting a shift in trial management preferences.

Interpretation:

Gamification may enhance engagement, education, and adherence in clinical trials, potentially improving retention and data completeness, but careful consideration of its implementation is necessary.

Limitations:

• Limited research on the long-term effects of gamification in clinical trials, indicating a need for longitudinal studies.
• The study's findings are based on self-reported perceptions, which may not accurately reflect actual outcomes and behaviors.

Conclusion:

Further research is needed to understand the impact of gamification on patient outcomes in clinical trials, particularly regarding long-term effects and real-world applicability.