To evaluate the accuracy and reliability of lung ultrasound (LUS) for diagnosing transient tachypnea of the newborn (TTN) through a meta-analysis, without restrictions on language or publication date.
Approach:
Data Sources: Relevant studies were retrieved from PubMed, Web of Science, the Cochrane Library, Ovid, Scopus, and Embase databases, without restrictions on language or publication date.
Key Findings:
Ten studies comprising 1,747 newborns were included in the analysis.
Pooled sensitivity of LUS for diagnosing TTN was 0.93 (95% CI: 0.78–0.98).
Pooled specificity was 0.99 (95% CI: 0.97–1.00).
The pooled diagnostic odds ratio (DOR) was 1113.94 (95% CI: 143.77–8631.13).
The area under the curve (AUC) was 0.97.
The pooled positive likelihood ratio (PLR) was 81.64 (95% CI: 26.19–254.45).
The pooled negative likelihood ratio (NLR) was 0.07 (95% CI: 0.02–0.24).
Interpretation:
The diagnostic accuracy of LUS for TTN varies considerably depending on study design and diagnostic criteria.
Limitations:
Variability in diagnostic accuracy based on study design and criteria.
Moderate to high overall methodological quality of included studies.
Conclusion:
Further studies are warranted to validate the utility of LUS in the diagnosis of TTN.
