Defining early carcinogenic markers for the prediction of the hazard potential of mineral fibres in an in vitro human 3D bronchial model - Summary - MDSpire

Defining early carcinogenic markers for the prediction of the hazard potential of mineral fibres in an in vitro human 3D bronchial model

  • By

  • Vanessa Almonti

  • Serena Mirata

  • Mario Passalacqua

  • Stefania Vernazza

  • Sara Tirendi

  • Sara Ferrando

  • Beatrice Risso

  • Elena Grasselli

  • Giulia De Negri Atanasio

  • Anna Maria Bassi

  • Alessandro F. Gualtieri

  • Sonia Scarfì

  • June 15, 2026

  • 0 min

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Objective:

To analyze the effects of different size fractions of chrysotile fibres on human bronchial epithelial tissues using the EpiAirway™ model and identify early carcinogenic markers.

Approach:
    Key Findings:
    • Chrysotile fibres are a significant environmental contaminant linked to serious health issues, including lung cancer.
    • The carcinogenic potential of chrysotile is debated, particularly regarding its biodurability compared to amphibole asbestos.
    • Morphometric parameters of asbestos fibres, such as length and width, are critical for assessing toxicity risk.
    Interpretation:

    Limitations:
    • The study focuses on specific size fractions of chrysotile and may not represent all asbestos types.
    • Long-term effects beyond 12 days were not assessed.
    Conclusion:

    This research contributes to the identification of early carcinogenic indicators related to chrysotile fibres.

Original Source(s)

Defining early carcinogenic markers for the prediction of the hazard potential of mineral fibres in an in vitro human 3D bronchial model

  • by Vanessa Almonti, Serena Mirata, Mario Passalacqua, Stefania Vernazza, Sara Tirendi, Sara Ferrando, Beatrice Risso, Elena Grasselli, Giulia De Negri Atanasio, Anna Maria Bassi, Alessandro F. Gualtieri, Sonia Scarfì

  • June 15, 2026

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