To evaluate the associations of neuroticism with vitamin D (VD) and vitamin B9 (VB9) using polygenic scores (PGS) in a nonclinical cohort, highlighting the significance of genetic factors in these associations.
Key Findings:
Negative association between VB9-PGS and neuroticism scores in women, suggesting a protective effect.
Positive association between VD-PGS and neuroticism scores in men, indicating a potential risk factor.
Men with high VD-PGS also scored high on neuroticism and extraversion, highlighting the interplay between these traits.
Interpretation:
The effects of genetic propensity for suboptimal vitamin D and B9 levels on neuroticism differ by sex, with vitamin B9 linked to emotional stability in women and vitamin D associated with excitability in men, suggesting avenues for targeted interventions.
Limitations:
Study limited to a nonclinical cohort, which may not generalize to clinical populations, and potential biases in sample selection.
Sample size may limit the robustness of findings, necessitating further research with larger cohorts.
Conclusion:
The study highlights the importance of considering gender differences in the relationship between vitamin levels and neuroticism, suggesting potential avenues for targeted interventions in public health and clinical settings.
