Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post - Summary - MDSpire

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post

  • By

  • Henri Lu

  • Annamaria Kosztin

  • Brian L. Claggett

  • Alberto Foà

  • Maria A. Pabón

  • Akshay S. Desai

  • Pardeep S. Jhund

  • Alasdair D. Henderson

  • Bela Merkely

  • Carolyn S. P. Lam

  • Michele Senni

  • Sanjiv J. Shah

  • Adriaan A. Voors

  • Faiez Zannad

  • Bertram Pitt

  • Flaviana Amarante

  • Riitta Saarinen

  • Yoriko De Sanctis

  • Andrea Glasauer

  • John J. V. McMurray

  • Muthiah Vaduganathan

  • Scott D. Solomon

  • June 1, 2026

  • 0 min

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Objective:

To examine temporal patterns of functional status, quality of life, and biomarkers in patients with heart failure prior to sudden death compared to other modes of death.

Approach:
    Key Findings:
    • Sudden death accounted for 25% to 30% of total deaths in HFpEF trials.
    • Current guidelines do not recommend ICDs for primary prevention in HFpEF due to insufficient evidence.
    • Distinct clinical and biological deterioration patterns may precede sudden death compared to other death modes.
    Interpretation:

    Remove this section as it contains unsupported claims.

    Limitations:
    • The analysis is based on a post hoc evaluation, which may introduce bias.
    • Data on trajectories may not be generalizable beyond the studied population.
    Conclusion:

    Revise to avoid implications about informing future strategies.

Original Source(s)

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post

  • by Henri Lu, Annamaria Kosztin, Brian L. Claggett, Alberto Foà, Maria A. Pabón, Akshay S. Desai, Pardeep S. Jhund, Alasdair D. Henderson, Bela Merkely, Carolyn S. P. Lam, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Bertram Pitt, Flaviana Amarante, Riitta Saarinen, Yoriko De Sanctis, Andrea Glasauer, John J. V. McMurray, Muthiah Vaduganathan, Scott D. Solomon

  • June 1, 2026

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