To develop a multifunctional hyaluronic acid-based hydrogel that enhances cellular adhesion and provides localized antimicrobial activity to accelerate the healing of diabetic foot ulcers (DFUs).
The presence of gelatin improved hydrogel stability without altering degradation profiles.
0.5% gelatin concentration was optimal for supporting cell adhesion and spreading.
Incorporation of AMP conferred bactericidal activity against S. aureus.
Interpretation:
The multifunctional AcHyA hydrogels show potential as effective wound dressings for DFUs, providing structural support, enhanced bioactivity, and localized antimicrobial effects.
Limitations:
The study primarily focused on in vitro assessments; pre-clinical models are needed for further validation.
Long-term effectiveness and safety in clinical settings remain to be evaluated.
Conclusion:
AcHyA hydrogels functionalized with gelatin and antimicrobial peptides demonstrate promising potential for promoting the healing of chronic wounds, warranting further research in pre-clinical models.
