To evaluate the predictive value of hematological and metabolic indices, including HRR, RAR, TyG index, and UA/Alb ratio, for 28-day mortality in patients with sepsis.
Key Findings:
Non-survivors had higher disease severity scores and distinct biochemical profiles (p < 0.001).
All evaluated indices were significantly associated with mortality.
The UA/Alb ratio had the highest predictive performance (AUC: 0.968).
The TyG index (AUC: 0.916) and RAR (AUC: 0.900) also showed strong predictive value.
In multivariable analysis, UA/Alb ratio and SAPS II score were independent predictors of mortality (p < 0.001).
Interpretation:
Hematological and metabolic indices can significantly improve early prediction of mortality in septic patients, with the UA/Alb ratio being the most predictive marker, highlighting its potential role in clinical decision-making.
Limitations:
Retrospective design may introduce bias and confounding factors.
Findings may not be generalizable beyond the studied population.
Conclusion:
Hematological and metabolic indices are valuable for predicting mortality in septic patients, with the UA/Alb ratio showing the highest discriminative performance, emphasizing the need for further validation in clinical practice.
