To characterize cardiomyopathy in women with acromegaly and identify clinical factors associated with its presence.
Approach:
Study Design: Secondary analysis of the multicenter RAPACO-Heart registry in Colombia focusing on women aged ≥18 years with confirmed acromegaly.
Data Collection: Clinical, anthropometric, biochemical, and echocardiographic data were analyzed, with cardiomyopathy defined by echocardiographic abnormalities.
Statistical Analysis: Multivariable logistic regression was used to identify factors independently associated with cardiomyopathy.
Key Findings:
A total of 116 women were included, of whom 34 (29.3%) had cardiomyopathy.
Women with cardiomyopathy were older (mean age not specified) and had longer disease duration.
Hypertension (p = 0.009), arrhythmias (p = 0.03), and carpal tunnel syndrome (p = 0.04) were more frequent in women with cardiomyopathy.
Age (adjusted OR 1.07 per year; 95% CI 1.03–1.12; p = 0.001), hypertension (adjusted OR 3.9; 95% CI 1.4–11.1; p = 0.009), arrhythmias (adjusted OR 2.8; 95% CI 1.1–7.4; p = 0.03), and carpal tunnel syndrome (adjusted OR 2.6; 95% CI 1.1–6.5; p = 0.04) were independently associated with cardiomyopathy.
Interpretation:
The findings indicate that cardiomyopathy is a significant complication among women with acromegaly, with a notable prevalence of associated clinical factors such as hypertension, arrhythmias, and carpal tunnel syndrome. The independent associations identified suggest that older age and longer disease duration may contribute to the development of cardiomyopathy in this population.
Limitations:
The study focused only on women, limiting generalizability to the male population.
Data were collected from routine clinical practice without centralized image analysis.
Conclusion:
The study highlights the importance of monitoring cardiovascular health in women with acromegaly, as cardiomyopathy is prevalent and associated with specific clinical factors. Early identification and management of these factors may improve outcomes for affected individuals. Further research is needed to explore the underlying mechanisms and to assess potential interventions. ---
by Santiago Sierra-Castillo, David Aristizabal-Colorado, Andres Arteaga-Arellano, Daniel Miranda-Brazales, Ysamar Aquino, Juan Andres Muñoz-Ordoñez, Daniel Sierra-Castillo, Juan C. Peláez Ortiz, David Alexander Vernaza Trujillo, Juan S. Izquierdo-Condoy, Clara Saldarriaga, Alin Abreu-Lomba
In a pooled analysis of two randomized crossover trials, reducing nightly sleep by about 1.5 hours for 6 weeks was associated with modest increases in body weight and waist circumference without measurable changes in body composition.
