To characterize cardiomyopathy in women with acromegaly and identify clinical factors associated with its presence.
Approach:
Study Design: Secondary analysis of the multicenter RAPACO-Heart registry in Colombia focusing on women aged ≥18 years with confirmed acromegaly.
Data Collection: Clinical, anthropometric, biochemical, and echocardiographic data were analyzed, with cardiomyopathy defined by echocardiographic abnormalities.
Statistical Analysis: Multivariable logistic regression was used to identify factors independently associated with cardiomyopathy.
Key Findings:
A total of 116 women were included, of whom 34 (29.3%) had cardiomyopathy.
Women with cardiomyopathy were older (mean age not specified) and had longer disease duration.
Hypertension (p = 0.009), arrhythmias (p = 0.03), and carpal tunnel syndrome (p = 0.04) were more frequent in women with cardiomyopathy.
Age (adjusted OR 1.07 per year; 95% CI 1.03–1.12; p = 0.001), hypertension (adjusted OR 3.9; 95% CI 1.4–11.1; p = 0.009), arrhythmias (adjusted OR 2.8; 95% CI 1.1–7.4; p = 0.03), and carpal tunnel syndrome (adjusted OR 2.6; 95% CI 1.1–6.5; p = 0.04) were independently associated with cardiomyopathy.
Interpretation:
Limitations:
The study focused only on women, limiting generalizability to the male population.
Data were collected from routine clinical practice without centralized image analysis.
by Santiago Sierra-Castillo, David Aristizabal-Colorado, Andres Arteaga-Arellano, Daniel Miranda-Brazales, Ysamar Aquino, Juan Andres Muñoz-Ordoñez, Daniel Sierra-Castillo, Juan C. Peláez Ortiz, David Alexander Vernaza Trujillo, Juan S. Izquierdo-Condoy, Clara Saldarriaga, Alin Abreu-Lomba
