Case Report: Gastric Signet-Ring-Cell Adenocarcinoma in a Young Adult with Tracheoesophageal Fistula/Esophageal Atresia and Complex Gastrointestinal History - Summary - MDSpire

Case Report: Gastric Signet-Ring-Cell Adenocarcinoma in a Young Adult with Tracheoesophageal Fistula/Esophageal Atresia and Complex Gastrointestinal History

  • By

  • Katrib, Amira

  • Babun, Asis

  • Wong, Lauren

  • Reynolds, Amberly

  • Nishimura, Makoto

  • April 21, 2026

  • 0 min

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Objective:

To present a case of gastric signet-ring-cell adenocarcinoma in a young female with a history of tracheoesophageal fistula and esophageal atresia, highlighting the challenges in diagnosis and management.

Key Findings:
  • SRC is rare in young adults and unusual in patients with congenital foregut anomalies.
  • Biopsy handling errors complicated tumor localization.
  • Endoscopic treatment restored esophageal patency and eliminated the need for repeat dilations.
Interpretation:

The case illustrates the relationship between congenital gastrointestinal anomalies and the development of SRC, emphasizing the need for careful biopsy techniques and individualized treatment approaches.

Limitations:
  • Biopsy handling errors may lead to misdiagnosis or mismanagement.
  • Limited generalizability due to the uniqueness of the case.
Conclusion:

Tailored surveillance may be beneficial in early-stage SRC cases with uncertain localization and negative imaging, highlighting the importance of personalized endoscopic care.

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