Acute Kidney Injury Therapies Reviewed - Summary - MDSpire

Acute Kidney Injury Therapies Reviewed

Several interventions show early promise in high-risk patients, yet the field still awaits its first proven targeted therapy.

  • By

  • Andrea Surnit

  • June 12, 2026

  • 5 min

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Objective:

To evaluate recent studies on preventive and therapeutic strategies for acute kidney injury (AKI) in critical care, with an emphasis on literature published in 2024 and 2025.

Key Findings:
  • Intravenous balanced amino acid mixture reduced AKI incidence in postoperative patients but did not improve long-term outcomes.
  • Oral inorganic nitrate reduced contrast-induced AKI incidence but has not been tested in critically ill patients.
  • Sodium-glucose cotransporter 2 inhibitors showed a lower risk of AKI in chronic-use populations.
  • Dexmedetomidine demonstrated potential kidney protection in perioperative settings.
  • Angiotensin II showed benefits in specific AKI stages but not universally.
  • Device-based approaches yielded mixed results in AKI prevention.
Interpretation:

Limitations:
  • Serum creatinine often detects kidney injury too late.
  • Distinct mechanisms of AKI may influence treatment responses.
Conclusion:

Sources:

Original Source(s)

Acute Kidney Injury Therapies Reviewed

  • by Andrea Surnit

  • June 12, 2026

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