HBV pgRNA induces chronic inflammation in an IL-1β-dependent manner - Summary - MDSpire

HBV pgRNA induces chronic inflammation in an IL-1β-dependent manner

  • By

  • Aikaterini Skeva

  • Konstantinos Marmanis

  • Maria Ntinopoulou

  • Panagiotis Liakopoulos

  • Eleni Tryfonopoulou

  • Anna Chalkidou

  • Stella Arelaki

  • Katerina Chlichlia

  • Maria Koffa

  • Akrivi Chrysanthopoulou

  • Petros Kolovos

  • Alexandra Giatromanolaki

  • Konstantinos Mimidis

  • Theocharis G. Konstantinidis

  • Maria Panopoulou

  • June 22, 2026

  • 0 min

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Objective:

To investigate the transcriptomic profile of pgRNA-positive patients with chronic hepatitis B (CHB) compared to pgRNA-negative patients.

Approach:
    Key Findings:
    • 18.1% of patients were positive for HBV pgRNA.
    • Differentially expressed genes involved in platelet activation and neutrophil degranulation were identified.
    • Platelets stimulated with HBV pgRNA-positive serum showed autophagy induction and LL-37 synthesis.
    Interpretation:

    HBV pgRNA activates platelets in an autophagy-dependent manner, contributing to chronic inflammation through the platelet-neutrophil axis.

    Conclusion:

    The study highlights the role of HBV pgRNA in activating platelets and inducing a proinflammatory response characterized by IL-1β overexpression.

Original Source(s)

HBV pgRNA induces chronic inflammation in an IL-1β-dependent manner

  • by Aikaterini Skeva, Konstantinos Marmanis, Maria Ntinopoulou, Panagiotis Liakopoulos, Eleni Tryfonopoulou, Anna Chalkidou, Stella Arelaki, Katerina Chlichlia, Maria Koffa, Akrivi Chrysanthopoulou, Petros Kolovos, Alexandra Giatromanolaki, Konstantinos Mimidis, Theocharis G. Konstantinidis, Maria Panopoulou

  • June 22, 2026

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