Vascular and autonomic correlates of screening-positive depressive symptom burden in chronic atrophic gastritis: a multicenter observational study protocol - Summary - MDSpire

Vascular and autonomic correlates of screening-positive depressive symptom burden in chronic atrophic gastritis: a multicenter observational study protocol

  • By

  • Meng Wang

  • Shunlei Jiang

  • Zixiang Jin

  • Xinyu Pan

  • Shijie Xu

  • Chao Wang

  • May 5, 2026

  • 0 min

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Objective:

To evaluate the association between vascular and autonomic measures and screening-positive depressive symptom burden in chronic atrophic gastritis, and to determine if these measures provide additional information beyond conventional clinical and histological variables, enhancing patient care.

Key Findings:
  • Depressive symptoms are often under-recognized in gastroenterology settings, impacting patient care.
  • Vascular dysfunction and arterial stiffness are linked to depressive symptoms.
  • Dorsalis pedis artery Doppler indices and brachial-ankle pulse wave velocity may serve as adjunctive assessment tools.
Interpretation:

The study aims to bridge the gap in recognizing depressive symptoms in patients with chronic atrophic gastritis by utilizing accessible vascular and autonomic measures, potentially improving patient care.

Limitations:
  • No participants have been enrolled and no data collected at the time of submission.
  • Focus on observational data may limit causal inferences.
  • Potential biases in self-reporting depressive symptoms may affect results.
Conclusion:

The study seeks to enhance the understanding of the relationship between vascular function and depressive symptoms in chronic atrophic gastritis, potentially improving patient care in gastroenterology.

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