Assessment of Organs at Risk (OARs) During Whole-Breast Radiation Therapy: A Comparative Analysis of Prone and Supine Positions with Deep Inspiration Breath-Hold Techniques from a Prospective Study Subgroup - Summary - MDSpire

Assessment of Organs at Risk (OARs) During Whole-Breast Radiation Therapy: A Comparative Analysis of Prone and Supine Positions with Deep Inspiration Breath-Hold Techniques from a Prospective Study Subgroup

  • By

  • Lingling Feng

  • Ying Liang

  • Jiaxin Huang

  • Sisi Xu

  • Wenjue Zhang

  • Xiaoye Su

  • Yutong Tan

  • Tongda Lei

  • Xiaoyong Xiang

  • Lining Chen

  • Junqin Lei

  • Nan Hu

  • Jing Jin

  • Qin Xiao

  • Ning Li

  • January 22, 2026

  • 0 min

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Objective:

To compare radiotherapy planning and organ at risk (OAR) doses in whole-breast irradiation using supine free-breathing, supine DIBH, and prone positioning techniques for both left- and right-sided breast cancer.

Key Findings:
  • DIBH significantly reduced mean heart dose (MHD) compared to supine FB.
  • Prone positioning resulted in lower lung exposure compared to both supine techniques.
  • Both DIBH and prone positioning effectively minimized radiation doses to OARs.
Interpretation:

The study highlights the effectiveness of DIBH and prone positioning in reducing radiation exposure to critical organs during whole-breast irradiation, suggesting these techniques may enhance patient safety and treatment outcomes.

Limitations:
  • Limited to a single center, which may affect generalizability.
  • Subgroup analysis may not capture all variables influencing outcomes.
  • Potential selection bias in patient eligibility for DIBH.
Conclusion:

DIBH and prone positioning are beneficial techniques for minimizing OAR doses during whole-breast radiation therapy, warranting further investigation in broader clinical settings.

Original Source(s)

Assessment of Organs at Risk (OARs) During Whole-Breast Radiation Therapy: A Comparative Analysis of Prone and Supine Positions with Deep Inspiration Breath-Hold Techniques from a Prospective Study Subgroup

  • by Lingling Feng, Ying Liang, Jiaxin Huang, Sisi Xu, Wenjue Zhang, Xiaoye Su, Yutong Tan, Tongda Lei, Xiaoyong Xiang, Lining Chen, Junqin Lei, Nan Hu, Jing Jin, Qin Xiao, Ning Li

  • January 22, 2026

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