Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates - Summary - MDSpire

Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates

  • By

  • Biprojit Nath

  • Samuel A. Bobholz

  • Daniel C. Kim

  • Allison K. Lowman

  • Savannah R. Duenweg

  • Aleksandra Winiarz

  • Benjamin Chao

  • Fitzgerald Kyereme

  • Michael Barrett

  • Hope M. Reecher

  • Jennifer Connelly

  • E. Kelly S. Mrachek

  • Jamie Jacobsohn

  • Max O. Krucoff

  • Elaine Tanhehco

  • Mohit Agarwal

  • Daniel Destiche

  • Anjishnu Banerjee

  • Peter S. LaViolette

  • February 21, 2026

  • 0 min

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Objective:

To characterize glymphatic dysfunction in glioblastoma (GBM) by integrating DTI-ALPS metrics, mpMRI features, and radio-pathomic maps of cell density, highlighting their interrelationships.

Key Findings:
  • DTI-ALPS indices were lower in regions with increased cellularity and tumor infiltration, indicating a potential marker for tumor aggressiveness.
  • Glymphatic dysfunction was observed in GBM, correlating with tumor characteristics, suggesting a link to patient prognosis.
  • Radio-pathomic maps effectively detected hypercellular tumor areas beyond contrast-enhancing margins, demonstrating their utility in clinical assessment.
Interpretation:

The findings suggest that GBM alters perivascular fluid transport, impacting glymphatic function, which may contribute to tumor progression and poor patient outcomes, warranting further investigation.

Limitations:
  • Study limited to IDH-wildtype GBM, which may not generalize to other GBM subtypes, potentially affecting the applicability of results.
  • Reliance on imaging data may overlook other physiological factors influencing glymphatic function, suggesting a need for complementary studies.
Conclusion:

This study highlights the potential of DTI-ALPS as a noninvasive marker for assessing glymphatic dysfunction in GBM, which could inform therapeutic strategies and improve patient management.

Original Source(s)

Altered perivascular diffusivity in glioblastoma: integrating DTI-ALPS index with radio-pathomic and histopathologic correlates

  • by Biprojit Nath, Samuel A. Bobholz, Daniel C. Kim, Allison K. Lowman, Savannah R. Duenweg, Aleksandra Winiarz, Benjamin Chao, Fitzgerald Kyereme, Michael Barrett, Hope M. Reecher, Jennifer Connelly, E. Kelly S. Mrachek, Jamie Jacobsohn, Max O. Krucoff, Elaine Tanhehco, Mohit Agarwal, Daniel Destiche, Anjishnu Banerjee, Peter S. LaViolette

  • February 21, 2026

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