Assessment of anti-nucleocapsid antibody presence as an indicator of SARS-CoV-2 infection among healthcare workers: a longitudinal seroprevalence investigation at a university hospital in Catalonia, Spain - Summary - MDSpire

Assessment of anti-nucleocapsid antibody presence as an indicator of SARS-CoV-2 infection among healthcare workers: a longitudinal seroprevalence investigation at a university hospital in Catalonia, Spain

  • By

  • Miquel Micó

  • Jaume Trapé

  • Laura González-García

  • Glòria Trujillo-Isern

  • Carolina González-Fernández

  • Joan López-Madueño

  • Silvia Bérgamo

  • Rafel Pérez-Vidal

  • Antonia Flor

  • Rosa Martínez-Montero

  • Jose Rives

  • Anna Arnau

  • Anna Fàbrega

  • February 6, 2026

  • 0 min

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Objective:

To establish the infection rate of SARS-CoV-2 among healthcare professionals by detecting anti-N antibodies, particularly in the context of a vaccination program.

Key Findings:
  • The study identified the presence of anti-N antibodies as a reliable indicator of past SARS-CoV-2 infection, with implications for understanding immunity.
  • Healthcare workers showed varying rates of infection despite vaccination, highlighting the need for ongoing monitoring and potential adjustments in public health strategies.
Interpretation:

The presence of anti-N antibodies in vaccinated healthcare workers indicates prior infection, emphasizing the importance of serological testing in understanding immunity and infection dynamics.

Limitations:
  • The study was limited to a single hospital setting, which may affect generalizability.
  • Participants were not systematically monitored for PCR/RAT, potentially missing asymptomatic cases, which could skew infection rate estimates.
Conclusion:

The findings underscore the significance of anti-N antibody testing in assessing SARS-CoV-2 infection rates among vaccinated healthcare workers, emphasizing the need for ongoing serological testing to inform future public health strategies.

Original Source(s)

Assessment of anti-nucleocapsid antibody presence as an indicator of SARS-CoV-2 infection among healthcare workers: a longitudinal seroprevalence investigation at a university hospital in Catalonia, Spain

  • by Miquel Micó, Jaume Trapé, Laura González-García, Glòria Trujillo-Isern, Carolina González-Fernández, Joan López-Madueño, Silvia Bérgamo, Rafel Pérez-Vidal, Antonia Flor, Rosa Martínez-Montero, Jose Rives, Anna Arnau, Anna Fàbrega

  • February 6, 2026

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