Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: a systematic review and meta-analysis - Summary - MDSpire
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Impact of haematopoietic stem cell transplantation for benign and malignant haematologic and non-haematologic disorders on fertility: a systematic review and meta-analysis
To systematically assess the gonadal toxicity of myoablative treatments (specifically chemotherapy and radiation) in both females and males with benign and malignant diseases and provide guidance on fertility preservation measures.
Key Findings:
HSCT is associated with a high risk of primary ovarian insufficiency (POI) and testicular failure, significantly impacting fertility.
Pregnancy rates post-HSCT are reported to be less than 5%, highlighting the need for effective fertility preservation strategies.
Fertility preservation measures are complex and vary between benign and malignant conditions, necessitating tailored approaches.
Interpretation:
The findings underscore the critical importance of fertility preservation counseling prior to HSCT, especially given the increasing survival rates and long-term complications associated with these treatments.
Limitations:
Heterogeneity of HSCT treatments complicates the summarization of gonadotoxicity, making it challenging to draw generalized conclusions.
Limited data on fertility outcomes in prepubertal patients restricts understanding of the full impact of HSCT on fertility.
Conclusion:
A comprehensive understanding of gonadal toxicity and fertility preservation options is essential for improving patient counseling and outcomes in individuals undergoing HSCT.
