Risk factors and prediction model for necrotizing enterocolitis in preterm infants with gestational age ≤ 32 weeks: a retrospective cohort study - Summary - MDSpire

Risk factors and prediction model for necrotizing enterocolitis in preterm infants with gestational age ≤ 32 weeks: a retrospective cohort study

  • By

  • Hao Li

  • GuiXiang Zeng

  • YaoXun Wu

  • Lin Cheng

  • LianFang Jing

  • HanLu Zhong

  • Yu Xie

  • Zhe Wei

  • KeMou Wu

  • Jun Fu

  • XiuLi Deng

  • HuaBo Tang

  • RenZhuang Huang

  • YanTing Lin

  • MingJie Lin

  • ShaSha Wei

  • DongMei Jiang

  • Yan Li

  • June 2, 2026

  • 0 min

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Objective:

To develop a reference tool for necrotizing enterocolitis (NEC) prevention and treatment by constructing a predictive model for NEC risk in preterm infants (≤32 weeks’ gestation) in Guangxi, China.

Key Findings:
  • The incidence of NEC among preterm infants was 12.27% (61/497).
  • Significant predictors identified included intrauterine growth restriction (IUGR), neonatal respiratory distress syndrome (NRDS), sepsis, and invasive ventilator use.
  • A higher 5-minute Apgar score was a protective factor against NEC.
  • The nomogram prediction model showed excellent discriminatory ability with AUC of 0.917 in the training set and 0.906 in the test set.
Interpretation:

Remove unsupported claims about the model's effectiveness.

Limitations:
  • Retrospective design may introduce bias.
  • Data limited to a specific geographic region (Guangxi, China).
  • Potential confounding factors not accounted for in the analysis.
Conclusion:

Revise to eliminate unsupported claims regarding guidance for prevention and treatment.

Original Source(s)

Risk factors and prediction model for necrotizing enterocolitis in preterm infants with gestational age ≤ 32 weeks: a retrospective cohort study

  • by Hao Li, GuiXiang Zeng, YaoXun Wu, Lin Cheng, LianFang Jing, HanLu Zhong, Yu Xie, Zhe Wei, KeMou Wu, Jun Fu, XiuLi Deng, HuaBo Tang, RenZhuang Huang, YanTing Lin, MingJie Lin, ShaSha Wei, DongMei Jiang, Yan Li

  • June 2, 2026

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