Cognition and health-related quality of life in long-term survivors of high-grade glioma: an interactive perspective from patient and caregiver - Summary - MDSpire
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Cognition and health-related quality of life in long-term survivors of high-grade glioma: an interactive perspective from patient and caregiver
To investigate the cognitive status of long-term survivors of high-grade glioma (HGG) and how cognitive functioning influences health-related quality of life (HRQoL) and caregiver burden.
Key Findings:
Long-term HGG survivors showed significantly lower cognitive test scores across all domains compared to normative data, indicating substantial cognitive impairment.
15 out of 21 patients exhibited cognitive impairments, with only one patient showing no impairments, highlighting the prevalence of cognitive issues.
Patients with longer survival (≥12 years) performed significantly lower on verbal memory tests, suggesting a potential decline in cognitive function over time.
Interpretation:
Cognitive impairments are prevalent in long-term HGG survivors, impacting their HRQoL and potentially increasing caregiver burden.
Limitations:
The small sample size of 21 patients may limit generalizability and the ability to detect subtle effects.
Exclusion of non-native Dutch speakers may introduce bias, potentially affecting the representativeness of the findings.
Conclusion:
Cognitive functioning in long-term HGG survivors is significantly impaired, underscoring the need for ongoing assessment and support for both patients and caregivers, and suggesting areas for future research.
by Jochem K. H. Spoor, Marike Donders-Kamphuis, Wencke S. Veenstra, Sarah A. van Dijk, Clemens M. F. Dirven, Peter A. E. Sillevis Smitt, Martin J. van den Bent, Sieger Leenstra, Djaina D. Satoer
