Objective:

To investigate the association between the triglyceride-high density lipoprotein cholesterol-glucose body index (TyHGB) and the risk of developing prediabetes or diabetes among middle-aged and elderly postmenopausal women.

Approach:

• Study Design: Longitudinal study using data from the REACTION study in Dalian, China, involving postmenopausal women with normal baseline glucose tolerance followed over three years.
• Statistical Analysis: Multivariable logistic regression was used to evaluate the relationship of TyHGB with incident prediabetes and diabetes, along with restricted cubic splines for dose-response relationships and ROC curve analysis for predictive performance.

Key Findings:

• Among the 2,138 participants, 598 developed prediabetes and 124 developed diabetes during follow-up.
• A significant positive association was found between TyHGB and the risk of both prediabetes and diabetes.
• Nonlinear dose-response relationship confirmed, with prediabetes risk increasing steeply below an inflection point of 8.52 and diabetes risk increasing sharply above 6.47.
• Subgroup analyses showed consistent associations across various strata including age, hypertension, hyperlipidemia, and coronary heart disease.
• TyHGB demonstrated effective predictive value for diabetes in postmenopausal women.

Interpretation:

The TyHGB index is an independent risk factor for prediabetes and diabetes in middle-aged and elderly postmenopausal women.

Limitations:

• The study was limited to a specific population in Dalian, China, which may affect generalizability.
• Potential biases related to self-reported data and follow-up loss may exist.

Conclusion:

The TyHGB index may serve as a marker for assessing diabetes risk in postmenopausal women.