Impaired Bone Tissue Quality Associated With Inflammation in HIV-immunological Nonresponders: A Cross-sectional Analysis - Summary - MDSpire

Impaired Bone Tissue Quality Associated With Inflammation in HIV-immunological Nonresponders: A Cross-sectional Analysis

  • By

  • Oriol Rins-Lozano

  • Jaime Rodríguez-Morera

  • Itziar Arrieta-Aldea

  • Alicia González-Mena

  • Sergi Rodríguez-Mercader

  • Lucía Suaya

  • Mariano Pascual-Aranda

  • Esperanza Cañas-Ruano

  • María José Fernandez-Quiroga

  • Cecilia Canepa

  • Juan Du

  • Agustín Marcos

  • Hernando Knobel

  • Natalia García-Giralt

  • Robert Güerri-Fernández

  • November 11, 2024

  • 0 min

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Objective:

To evaluate bone quality in immunological nonresponders (INRs) compared to those with proper immune response (IRs) using in vivo microindentation and conventional bone mineral density (BMD) evaluations, highlighting the clinical significance of these differences.

Key Findings:
  • INRs had worse bone quality with lower median bone material strength index compared to IRs (79 [76-87] vs 86 [82-89]; P < .001).
  • Similar BMD levels were observed between INRs and IRs.
  • INRs exhibited increased high-sensitive C-reactive protein levels and lower 25-(OH)-vitamin D3.
  • A significant negative correlation between inflammation and bone quality was found, especially in INRs.
  • INR status is a major predictor of decreased bone quality, independent of conventional risk factors.
Interpretation:

Higher inflammatory levels in INRs may contribute to poorer bone quality, indicating a need for targeted interventions in this subgroup of PWH to improve their overall health outcomes.

Limitations:
  • Cross-sectional design limits causal inferences, making it difficult to establish direct relationships.
  • Study conducted at a single center may affect generalizability to broader populations.
  • Potential confounding factors not fully accounted for, which may influence the results.
Conclusion:

Further studies are needed to confirm these results and to explore non-AIDS comorbidities in INRs, highlighting the importance of monitoring bone health in this population and the urgency for targeted interventions.

Original Source(s)

Impaired Bone Tissue Quality Associated With Inflammation in HIV-immunological Nonresponders: A Cross-sectional Analysis

  • by Oriol Rins-Lozano, Jaime Rodríguez-Morera, Itziar Arrieta-Aldea, Alicia González-Mena, Sergi Rodríguez-Mercader, Lucía Suaya, Mariano Pascual-Aranda, Esperanza Cañas-Ruano, María José Fernandez-Quiroga, Cecilia Canepa, Juan Du, Agustín Marcos, Hernando Knobel, Natalia García-Giralt, Robert Güerri-Fernández

  • November 11, 2024

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