Association of body mass index on 10-year outcomes in patients treated with percutaneous coronary intervention and drug-eluting stents (the DECADE cooperation) - Summary - MDSpire

Association of body mass index on 10-year outcomes in patients treated with percutaneous coronary intervention and drug-eluting stents (the DECADE cooperation)

  • By

  • Maria Scalamogna

  • Fiorenzo Simonetti

  • John Joseph Coughlan

  • Luis Ortega-Paz

  • Lorenz Räber

  • Lisette Okkels Jensen

  • Michael Maeng

  • Salvatore Brugaletta

  • Sebastian Kufner

  • Sarah Bär

  • Karl-Ludwig Laugwitz

  • Dik Heg

  • Manel Sabaté

  • Stephan Windecker

  • Kevin Kris Warnakula Olesen

  • Adnan Kastrati

  • Salvatore Cassese

  • November 24, 2025

  • 0 min

Share

Objective:

To assess the association between body mass index (BMI) and 10-year clinical outcomes, including all-cause death, cardiovascular death, myocardial infarction, definite stent thrombosis, and repeat revascularization, in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation.

Key Findings:
  • Underweight patients had a significantly higher risk of all-cause death compared to normal-weight patients (HRadj, 1.58; 95% CI, 1.01–2.47).
  • Overweight patients had a lower risk of all-cause death compared to normal-weight patients (HRadj, 0.84; 95% CI, 0.78–0.90).
  • Obese patients showed comparable all-cause death rates to normal-weight patients (HRadj, not significant).
  • Overweight and obese patients had a higher risk of definite stent thrombosis within 30 days post-PCI (HRadj, not specified).
  • Obese patients had a lower risk of repeat revascularization compared to normal-weight patients (HRadj, not specified).
  • A U-shaped, non-linear association was observed between BMI and both all-cause and cardiovascular death.
Interpretation:

The baseline BMI of patients undergoing PCI with DES significantly influences long-term outcomes, suggesting the need for tailored secondary prevention strategies to improve patient management.

Limitations:
  • The analysis is based on pooled data from trials, which may introduce variability in patient characteristics and outcomes.
  • Further dedicated studies are required to validate findings and address limitations related to data pooling.
Conclusion:

The study highlights the importance of BMI in predicting long-term outcomes after PCI with DES, indicating potential implications for patient management and the necessity for further research.

Original Source(s)

Association of body mass index on 10-year outcomes in patients treated with percutaneous coronary intervention and drug-eluting stents (the DECADE cooperation)

  • by Maria Scalamogna, Fiorenzo Simonetti, John Joseph Coughlan, Luis Ortega-Paz, Lorenz Räber, Lisette Okkels Jensen, Michael Maeng, Salvatore Brugaletta, Sebastian Kufner, Sarah Bär, Karl-Ludwig Laugwitz, Dik Heg, Manel Sabaté, Stephan Windecker, Kevin Kris Warnakula Olesen, Adnan Kastrati, Salvatore Cassese

  • November 24, 2025

Related Content

Epicardial fat area as an independent predictor of atrial fibrillation occurrence and severity

Diabetes Risk Scores: Beyond Glucose

Multi-ancestry polygenic models identify high-risk patients traditional screening may miss.

GLP-1 Drugs Tied to Lower Addiction Risk

In a target-trial emulation of more than 600,000 veterans, GLP-1 RA initiators saw fewer new substance use disorders—and patients with existing SUDs had fewer overdoses, hospitalizations, and deaths.