D-VRD induction and autologous transplant in patients ≥70 years - Summary - MDSpire

D-VRD induction and autologous transplant in patients ≥70 years

  • By

  • Oren Pasvolsky

  • Curtis Marcoux

  • Denái R. Milton

  • Mark R. Tanner

  • Muhammad Bilal Islam

  • Qaiser Bashir

  • Samer Srour

  • Neeraj Saini

  • Paul Lin

  • Jeremy Ramdial

  • Yago Nieto

  • Guilin Tang

  • Yosra Aljawai

  • Asad A. Haider

  • Hans C. Lee

  • Krina K. Patel

  • Partow Kebriaei

  • Sheeba K. Thomas

  • Robert Z. Orlowski

  • Richard E. Champlin

  • Elizabeth J. Shpall

  • Muzaffar H. Qazilbash

  • June 5, 2026

  • 0 min

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Objective:

To evaluate the outcomes of newly diagnosed multiple myeloma patients aged ≥70 years treated with D-VRD induction followed by autologous hematopoietic cell transplantation (autoHCT).

Key Findings:
  • 125 patients were included: 27 (22%) older and 98 (78%) younger.
  • No non-relapse mortality events occurred in either group.
  • Pre-transplant response rates were similar: ≥ very good partial response (VGPR) in 81% older vs 78% younger patients.
  • Median follow-up was 19.1 months; median PFS was 36.5 months in older patients.
  • One- and two-year OS rates were 100% and 92% in older patients vs 98% and 93% in younger patients.
Interpretation:

Limitations:
  • The study is retrospective and may have selection bias.
  • Limited generalizability due to the specific patient population and treatment protocols.
Conclusion:

Original Source(s)

D-VRD induction and autologous transplant in patients ≥70 years

  • by Oren Pasvolsky, Curtis Marcoux, Denái R. Milton, Mark R. Tanner, Muhammad Bilal Islam, Qaiser Bashir, Samer Srour, Neeraj Saini, Paul Lin, Jeremy Ramdial, Yago Nieto, Guilin Tang, Yosra Aljawai, Asad A. Haider, Hans C. Lee, Krina K. Patel, Partow Kebriaei, Sheeba K. Thomas, Robert Z. Orlowski, Richard E. Champlin, Elizabeth J. Shpall, Muzaffar H. Qazilbash

  • June 5, 2026

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