Preop Cognitive Impairment Tied to TKA Delirium - Summary - MDSpire

Preop Cognitive Impairment Tied to TKA Delirium

  • By

  • Andrea Surnit

  • May 13, 2026

  • 4 min

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Objective:

To investigate the impact of preoperative cognitive impairment on postoperative outcomes in older patients undergoing elective total knee arthroplasty (TKA).

Key Findings:
  • Postoperative delirium occurred in 27% of patients with cognitive impairment vs <1% in those without (OR 40.15; 95% CI, 5.3–304.13).
  • Only 17% of patients with cognitive impairment remained independent postoperatively compared to 48% without (p = 0.029).
  • 50% of patients with cognitive impairment had nonhome discharge vs 36% without.
Interpretation:

Preoperative cognitive impairment is significantly associated with higher rates of postoperative delirium and functional dependence, suggesting the need for early identification and intervention to improve outcomes.

Limitations:
  • Retrospective observational design may introduce bias.
  • Cognitive impairment identified through clinical documentation may underestimate true prevalence.
  • Postoperative delirium assessed via chart audit rather than standardized assessments.
  • Lack of standardized information regarding postoperative rehabilitation and physical therapy exposure.
Conclusion:

Identifying patients with cognitive impairment preoperatively and implementing preventive strategies may reduce adverse postoperative outcomes.

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