To provide a comprehensive bibliometric mapping of the intellectual structure and research frontiers in the field of epigenetics related to bipolar disorder (BD), highlighting its significance in advancing research.
Key Findings:
A total of 1154 valid documents were included in the analysis.
The United States was the most productive country, with Harvard University as the leading institution.
Kato T and Nöthen MM were identified as the most prolific author and highly co-cited scientist, respectively.
Molecular Psychiatry was the core journal with the highest publication volume and citation frequency.
Current research frontiers include histone modifications, HDAC inhibitors, long noncoding RNAs, and the interplay between genetic variants and epigenetic regulation, which may lead to novel therapeutic strategies.
Interpretation:
The study outlines the developmental trajectory of epigenetic research in BD, indicating a shift towards exploring dynamic regulatory networks and multi-omics integration, which may influence future research directions.
Limitations:
The study is limited to publications in English and may not capture all relevant research in other languages.
Non-original research documents such as reviews and editorials were excluded, potentially omitting valuable insights.
The reliance on specific databases may introduce biases in the selection of relevant literature.
Conclusion:
The findings provide a structural overview of current research hotspots and highlight directions for future clinical translation and targeted epigenetic interventions, emphasizing their importance in clinical practice.
Chemsex at the pharmacy counter. Gut bacteria tracking helmet impacts. PMD predicting psychiatric illness bidirectionally. This week's research keeps landing in the same uncomfortable place: medicine is improvising.
