Effect of general anesthesia on postoperative outcomes of transcatheter aortic valve implantation in patients: a systematic review and meta-analysis - Summary - MDSpire
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Effect of general anesthesia on postoperative outcomes of transcatheter aortic valve implantation in patients: a systematic review and meta-analysis
To evaluate the effects of general anesthesia on the prognosis of patients undergoing transcatheter aortic valve implantation (TAVI).
Approach:
Literature Search: The Cochrane Library, PubMed, Embase, and Medline databases were searched from inception to May 2025.
Meta-Analysis: A total of 38 eligible studies involving 23,848 patients were included in the meta-analysis using RevMan 5.3.
Key Findings:
In-hospital mortality was higher in the GA group (RR = 1.99, 95% CI, 1.19–3.30, P = 0.008).
Incidence of postoperative pneumonia increased in the GA group (RR = 2.39, 95% CI, 1.43–4.00, P = 0.0009).
Procedure time was longer in the GA group (MD = 20.22, 95% CI, 15.37–25.07, P < 0.00001).
Length of hospital stay was extended in the GA group (MD = 1.43, 95% CI, 1.10–1.76, P < 0.00001).
ICU stay was longer in the GA group (SMD = 1.91, 95% CI, 1.40–2.42, P < 0.00001).
No significant differences in 30-day mortality, postoperative acute kidney injury, stroke, vascular complications, or myocardial infarction.
Interpretation:
General anesthesia is associated with increased in-hospital mortality and postoperative pulmonary infections, prolonged hospitalization and ICU stay, but does not affect certain other postoperative complications.
Limitations:
Variability in study endpoints and observation indexes.
Differences in sample sizes across studies.
Conclusion:
The choice of anesthesia for TAVI should be carefully considered based on the specific circumstances of each patient. Further randomized controlled trials are needed.
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