To identify participant characteristics associated with the selection of centralized or remote engagement in a clinical trial focused on genomic research results.
Key Findings:
40% of participants chose centralized engagement, 49.9% remote, and 10.1% mixed (P < .001).
Young adults preferred centralized engagement (57.3%), while adolescent-parent dyads preferred remote (68.5%).
Participants living within 10 miles of CCHMC were more likely to choose centralized or mixed modalities (P = .01).
Interpretation:
Remote engagement was favored by adolescents and those living farther from the research site, indicating potential barriers for young adults in fully remote studies, which may inform future trial designs.
Limitations:
The study was not originally designed to assess engagement preferences, which may limit the findings.
Participants were limited to English speakers within 100 miles of CCHMC, potentially introducing selection bias.
Conclusion:
The hybrid trial design allowed for participant choice, achieving recruitment targets while accommodating diverse preferences, highlighting the importance of flexibility in trial designs.
