Psychological stress and diastolic blood pressure in cardiology outpatients: a multicenter cross-sectional study (from the ABC2X-2026 study) - Summary - MDSpire

Psychological stress and diastolic blood pressure in cardiology outpatients: a multicenter cross-sectional study (from the ABC2X-2026 study)

  • By

  • Giuseppe Berton

  • Mattia Ludovico Dario

  • David Merotto

  • Rocco Cordiano

  • Elena Selvestrel

  • Silvia Rui

  • Heba Talat Mahmoud

  • June 17, 2026

  • 0 min

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Objective:

To investigate the association between psychological stress and cardiovascular parameters in cardiology outpatients, specifically distinguishing between ongoing (present) and past (previous) stress.

Approach:
    Key Findings:
    • 55% of patients reported psychological stress: 39% with present stress and 16% with previous stress.
    • Present stress was associated with higher diastolic blood pressure (DBP) (β = 3.0 ± 0.9 mmHg, p = 0.001).
    • Previous stress was not significantly associated with DBP.
    • The association between present stress and DBP was stronger in patients with coronary artery disease (CAD) (β = 5.9 ± 2.4 mmHg, p = 0.01).
    Interpretation:

    Psychological stress is prevalent among cardiology outpatients and has distinct hemodynamic correlates based on its timing, with ongoing stress linked to higher DBP, suggesting a need for routine assessment in clinical practice.

    Limitations:
    • The study is cross-sectional, limiting causal inferences.
    • Stress assessment relied on clinical interviews, which may introduce bias.
    • Consideration of sample size and demographic diversity may enhance the findings.
    Conclusion:

    Routine assessment of psychological stress may enhance cardiovascular risk stratification in outpatient practice.

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