To identify and compare the bacteriological agents for early and late-onset neonatal sepsis and evaluate their antibiotic sensitivity patterns among neonates admitted to a tertiary care hospital in Nepal, highlighting the significance of these findings for local healthcare.
Key Findings:
Common causative agents of EONS included Escherichia coli and Group B Streptococci, with prevalence rates of X% and Y%, respectively.
Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, CoNS, and Group B Streptococci were prevalent in LONS, with Z% prevalence.
Antibiotic resistance patterns were observed, with a notable presence of multidrug-resistant (MDR) strains, affecting A% of isolates.
Interpretation:
The study highlights significant differences in bacteriological profiles and antibiotic resistance patterns between early and late-onset neonatal sepsis, emphasizing the need for tailored treatment strategies to improve outcomes.
Limitations:
The study was limited to a single tertiary care facility, which may affect the generalizability of the findings to other settings.
Exclusion of neonates with congenital malformations and severe cardiac abnormalities may limit the understanding of sepsis in a broader population, potentially overlooking important risk factors.
Conclusion:
The findings underscore the importance of continuous monitoring of bacteriological agents and antibiotic resistance in neonatal sepsis to improve clinical outcomes, particularly in resource-limited settings.
