Impact of Carbonated Water on Metrics of High-Resolution Esophageal Manometry: A Retrospective Analysis - Summary - MDSpire

Impact of Carbonated Water on Metrics of High-Resolution Esophageal Manometry: A Retrospective Analysis

  • By

  • Chih-Wen Huang

  • Yang-Yuan Chen

  • Hsu-Heng Yen

  • December 2, 2025

  • 0 min

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Objective:

To assess the impact of carbonated water on esophageal motility and its potential application for differentiating esophageal motility disorders (EMDs), highlighting its clinical significance.

Key Findings:
  • Carbonated water consumption influenced esophageal motility metrics, showing significant differences in DCI and IRP compared to still water, with p-values indicating statistical significance.
  • Changes in EMD diagnoses were observed after carbonated water consumption, with some patients showing improvement in motility classification, quantified by the number of patients affected.
  • The study identified potential predictors for changes in EMD diagnosis post-consumption, warranting further exploration.
Interpretation:

Carbonated water may serve as a useful tool in HRM to differentiate EMDs, potentially enhancing diagnostic accuracy and impacting treatment decisions.

Limitations:
  • Retrospective design may introduce selection bias and reliance on patient self-reporting.
  • Single-center study limits generalizability of findings.
  • Potential confounding factors not fully controlled, necessitating cautious interpretation.
Conclusion:

Carbonated water has a measurable impact on esophageal motility metrics and may aid in the diagnosis of EMDs, warranting further investigation in larger, multi-center studies to validate these findings.

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