Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study - Summary - MDSpire

Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study

  • By

  • Tatjana Dell

  • Verena Tischler

  • Dario Zocholl

  • Narine Mesropyan

  • Alice Margarida Jacob

  • Johannes Chang

  • Bernhard Schmidt

  • Claus Christian Pieper

  • Alexander Isaak

  • Patrick Kupczyk

  • Carsten Meyer

  • Julian Luetkens

  • Christian Strassburg

  • Christian Jansen

  • Daniel Kuetting

  • December 23, 2025

  • 0 min

Share

Objective:

To evaluate whether PCCT-derived ECV can stratify the risk of CSPH using noninvasive surrogates, such as liver stiffness measurement (LSM), and histology.

Key Findings:
  • PCCT-derived ECV shows strong correlation with fibrosis severity, indicating its potential as a reliable marker.
  • ECV quantification may serve as a noninvasive marker for CSPH risk stratification, enhancing clinical decision-making.
  • PCCT offers improved sensitivity and reproducibility over traditional imaging methods, which may lead to better patient outcomes.
Interpretation:

The study suggests that PCCT-derived ECV could enhance noninvasive assessment of CSPH, potentially improving patient management in chronic liver disease by providing more accurate risk stratification.

Limitations:
  • Study limited to patients undergoing HCC surveillance, which may not represent the broader population.
  • Potential biases in ECV measurement due to operator dependency and patient variability.
  • The limited population may affect the generalizability of the findings to all patients with chronic liver disease.
Conclusion:

PCCT-derived ECV is a promising tool for noninvasive risk stratification of CSPH, warranting further validation in larger cohorts.

Original Source(s)

Photon-counting CT-derived hepatic extracellular volume quantification for noninvasive risk stratification of clinically significant portal hypertension (CSPH): a prospective cohort study

  • by Tatjana Dell, Verena Tischler, Dario Zocholl, Narine Mesropyan, Alice Margarida Jacob, Johannes Chang, Bernhard Schmidt, Claus Christian Pieper, Alexander Isaak, Patrick Kupczyk, Carsten Meyer, Julian Luetkens, Christian Strassburg, Christian Jansen, Daniel Kuetting

  • December 23, 2025

Related Content

Beyond the radiology report: a multi-criteria decision analysis to define essential CT parameters for abdominal wall reconstruction

Early Enteral Feeding Tied to Fewer Complications

Benefit driven by fewer infections and pulmonary events, though overall complication rates were similar

AI Drafts Cut Radiograph Reporting Time

Prospective cohort study found faster documentation, with no statistically significant difference in peer-reviewed report quality