Objective:

To analyze demographic and regional patterns of malignant neoplasms of bone and articular cartilage (MNBAC) mortality in the U.S. from 1999 to 2023 and identify high-risk populations, such as age and race groups, for targeted interventions.

Key Findings:

• The South had the highest AAMR (0.60 in 1999, 0.68 in 2023), while the West showed the steepest increase in mortality rates (AAPC = 1.33).
• Individuals aged ≥75 years experienced the most significant increases in crude mortality rates (AAPC = 0.90 for 75-84; AAPC = 1.89 for 85+).
• Hispanics had the fastest AAMR increase (AAPC = 1.01), while non-Hispanic whites maintained the highest AAMR (0.68).
• Metropolitan areas exhibited greater increases in AAMR compared to non-metropolitan areas (AAPC = 0.84 vs. 0.27).
• Males consistently showed higher AAMRs than females (0.65 vs. 0.45 in 1999; 0.72 vs. 0.53 in 2023).

Interpretation:

Significant disparities in MNBAC mortality exist, particularly among males, Southerners, and non-Hispanic whites, indicating a critical need for targeted interventions to address these disparities.

Limitations:

• Data cells with <10 deaths were suppressed and not included in trend analyses.
• The study only included individuals aged 25 years and older, which may limit the generalizability of findings.

Conclusion:

The findings underscore the need for targeted interventions to improve outcomes and reduce mortality among high-risk populations.