Inflammatory Biomarkers and Respiratory Function in Liver Transplant Patients: Findings from a Nationwide Cohort Analysis - Summary - MDSpire

Inflammatory Biomarkers and Respiratory Function in Liver Transplant Patients: Findings from a Nationwide Cohort Analysis

  • By

  • Nicoline Arentoft

  • Julie Høgh

  • Hans-Christian Pommergaard

  • Andreas Dehlbæk Knudsen

  • Annette Dam Fialla

  • Paul Suno Krohn

  • Niels Kristian Aagaard

  • Jens-Ulrik Stæhr Jensen

  • Jesper Rømhild Davidsen

  • Michael Perch

  • Allan Rasmussen

  • Susanne Dam Nielsen

  • April 28, 2026

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Objective:

To investigate the correlation between elevated inflammatory markers and impaired lung function in liver transplant recipients.

Key Findings:
  • 11.6% prevalence of airflow limitation and 24.5% prevalence of PRISm among participants.
  • Median FEV1 was 2790 mL (IQR 2230–3505 mL) and median FVC was 3680 mL (IQR 2980–3755 mL).
  • hs-CRP >3 mg/L was associated with increased odds of PRISm (aOR 2.08) and lower FEV1 and FVC.
Interpretation:

Elevated hs-CRP levels indicate a potential link between systemic inflammation and impaired lung function in liver transplant recipients, suggesting a need for monitoring and management of respiratory health in this population.

Limitations:
  • Cross-sectional design limits causal inference.
  • Potential confounding factors such as smoking status and BMI not fully accounted for despite adjustments.
Conclusion:

Elevated hs-CRP is associated with impaired lung function in liver transplant recipients, suggesting systemic inflammation may contribute to respiratory issues in this population.

Original Source(s)

Inflammatory Biomarkers and Respiratory Function in Liver Transplant Patients: Findings from a Nationwide Cohort Analysis

  • by Nicoline Arentoft, Julie Høgh, Hans-Christian Pommergaard, Andreas Dehlbæk Knudsen, Annette Dam Fialla, Paul Suno Krohn, Niels Kristian Aagaard, Jens-Ulrik Stæhr Jensen, Jesper Rømhild Davidsen, Michael Perch, Allan Rasmussen, Susanne Dam Nielsen

  • April 28, 2026

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