The combined use of in vivo confocal microscopy and optical coherence tomography in monitoring corneal infections - Summary - MDSpire

The combined use of in vivo confocal microscopy and optical coherence tomography in monitoring corneal infections

  • By

  • Farida Omar ElZawahry

  • Sarah Donatelli

  • Mario Nubile

  • Prity Sahay

  • Dalia G. Said

  • Harminder S. Dua

  • June 9, 2026

  • 0 min

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Objective:

To evaluate the effectiveness of in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in diagnosing and monitoring infectious keratitis (IK).

Approach:
    Key Findings:
    • OCT provides non-contact, high magnification images but is limited by back shadowing in dense infiltrates.
    • IVCM allows for cellular-level examination and can visualize invading organisms with high sensitivity and specificity.
    • Deep learning models show promise for IK diagnosis but face challenges such as the need for large datasets and misclassification bias.
    Interpretation:

    Remove unsupported conclusions.

    Limitations:
    • The study was limited to a single center and a small sample size of 35 patients.
    • The reliance on imaging quality and the need for experienced interpretation skills may affect outcomes.
    Conclusion:

    Remove unsupported claims.

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