To evaluate the therapeutic efficacy of BufeiJianpi Mixture (BFJPM), a modified herbal formula developed for managing allergic constitution in children, in an OVA-induced murine model of food allergy and investigate its effects on gut microbiota.
Key Findings:
BFJPM reduced allergy symptom scores and serum total IgE levels in FA mice.
BFJPM improved the V/C ratio in FA mice.
Gut microbiota composition showed significant differences among groups, with increased microbial richness and altered community structure, including enrichment of Actinobacteria and Candidatus Arthromitus.
Saccharopolyspora was identified as a promising genus associated with BFJPM intervention and negatively correlated with serum IgE levels.
IL6, TNF, and IL10 were identified as major targets of BFJPM in food allergy.
Interpretation:
BFJPM alleviated food allergy symptoms and improved intestinal mucosal integrity in OVA-induced FA mice, with these effects accompanied by remodeling of the gut microbiota.
Limitations:
The causal relationship between microbiota remodeling and therapeutic efficacy remains to be established, which may impact the interpretation of BFJPM's effectiveness.
Conclusion:
BFJPM may represent a potential therapeutic approach for managing food allergies, with implications for gut microbiota modulation.
