Examining the Impact of Vaccination, Preexisting Health Issues, and Employment in Healthcare on Socioeconomic Inequalities in COVID-19 Hospitalization: A Mediation Analysis Utilizing Interventional Effect Models - Summary - MDSpire

Examining the Impact of Vaccination, Preexisting Health Issues, and Employment in Healthcare on Socioeconomic Inequalities in COVID-19 Hospitalization: A Mediation Analysis Utilizing Interventional Effect Models

  • By

  • Lisa Cavillot

  • Beatrijs Moerkerke

  • Brecht Devleesschauwer

  • Jinane Ghattas

  • Joris A. F. van Loenhout

  • Laura Van den Borre

  • Niko Speybroeck

  • Tom Loeys

  • Robby De Pauw

  • February 19, 2026

  • 0 min

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Objective:

To identify the mediating effect of vaccination, underlying health conditions, and health literacy (proxied by having a degree in healthcare) on the association between education and COVID-19 hospitalization among infected Belgian adults.

Key Findings:
  • Disadvantaged socioeconomic groups are overrepresented in essential occupations, increasing their risk of COVID-19 exposure, which necessitates policy intervention.
  • Lower socioeconomic groups have poorer baseline health conditions, leading to higher susceptibility to severe COVID-19 outcomes.
  • Vaccination coverage disparities exist, with lower education individuals being significantly less likely to receive vaccinations, highlighting a need for targeted outreach.
Interpretation:

Vaccination, underlying health conditions, and health literacy mediate the relationship between socioeconomic status and severe COVID-19 outcomes, underscoring the urgent need for targeted public health interventions.

Limitations:
  • The study focused only on the Walloon and Brussels regions, limiting generalizability to the entire Belgian population.
  • Data was only available for a specific timeframe, which may not capture long-term trends.
  • Potential biases in data collection or analysis could affect the results.
Conclusion:

Addressing health literacy and improving vaccination access in lower socioeconomic groups is crucial to mitigate COVID-19 health disparities.

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