To uncover the relationship between drug-induced osteoporosis and gut microbiota based on preclinical and clinical studies.
Key Findings:
Drug-induced osteoporosis is linked to alterations in gut microbiota.
Mechanisms of osteoporosis include changes in bone metabolism and microbial community structure.
There is limited direct evidence connecting drug-induced gut microbiota changes to bone turnover or fracture risk.
Interpretation:
The mechanisms linking individual drugs, gut microbiota, and bone health remain largely unresolved.
Limitations:
Lack of direct evidence for the mediating role of gut microbiota in drug-induced osteoporosis.
Need for more comprehensive clinical studies to validate findings.
Conclusion:
Therapeutic approaches for medication-induced osteoporosis include pharmacological interventions, adequate nutrient intake, exercise, and monitoring of bone mineral density, with potential future options in probiotic and prebiotic supplementation.
