To assess the characteristics and prognostic implications, specifically survival outcomes, of patients with elevated NLR 1 year after colorectal cancer surgery and to evaluate factors influencing NLR elevation.
Key Findings:
Persistent elevation of NLR 1 year post-surgery is associated with poor prognosis, as indicated by survival analysis.
NLR values were analyzed both as continuous and categorical variables, with a cut-off of 3.3 determined through receiver operating characteristic analysis.
Factors influencing NLR elevation included tumor stage, postoperative complications, and comorbidities.
Interpretation:
Elevated NLR after 1 year may indicate ongoing systemic inflammation and could serve as a prognostic marker for colorectal cancer patients.
Limitations:
The study did not collect data on excluded patients, which may limit generalizability and introduce bias in the findings.
Potential confounding factors related to postoperative care and patient management were not fully addressed, which could affect the interpretation of NLR elevation.
Conclusion:
Monitoring NLR postoperatively may provide valuable prognostic information for colorectal cancer patients, warranting further investigation into its clinical implications and potential interventions.
by David Ortíz-López, Joaquín Marchena-Gómez, Yurena Sosa-Quesada, Manuel Artiles-Armas, Beatriz Arencibia-Pérez, Julia Gil-García, Eva Nogués-Ramía, Cristina Roque-Castellano
