Small intestinal metastasis of triple-negative breast cancer mimicking lymphoma: imaging findings and case report - Summary - MDSpire

Small intestinal metastasis of triple-negative breast cancer mimicking lymphoma: imaging findings and case report

  • By

  • Lin-Ying Ma

  • Xiao-Shan Huang

  • Shu-Feng Fan

  • Li-Ming Xue

  • July 9, 2026

  • 0 min

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Objective:

To present a rare case of small intestinal metastasis from triple-negative breast cancer and discuss its imaging characteristics and diagnostic challenges.

Approach:
  • Case Presentation: A 70-year-old female with a history of bilateral breast cancer presented with unexplained anemia, dizziness, and positive fecal occult blood tests.
  • Imaging and Diagnosis: Contrast-enhanced CT revealed segmental wall thickening of the small bowel, initially raising suspicion for lymphoma. Double-balloon enteroscopy identified a large ulcerative lesion, leading to biopsy and histopathological evaluation.
Key Findings:
  • The patient had a history of invasive ductal carcinoma of triple-negative phenotype.
  • Initial presentation with anemia was atypical for small bowel metastasis from breast cancer.
  • Histopathological evaluation confirmed small intestinal metastasis from breast cancer.
Interpretation:

Clinicians should consider small bowel metastasis in breast cancer survivors presenting with unexplained anemia and positive fecal occult blood tests.

Limitations:
  • The case highlights the rarity of small intestinal metastasis from breast cancer, which can lead to diagnostic delays.
  • The initial imaging findings may be misleading, resembling lymphoma.
Conclusion:

A multidisciplinary approach is essential for accurate diagnosis and to minimize delays in treatment.

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