Objective:

To evaluate the performance of Dr. NEAR flow (DNF) in estimating hemodynamic parameters from time-of-flight magnetic resonance angiography (TOF-MRA) and to compare DNF-calculated velocities with Transcranial Doppler (TCD) measurements.

Approach:

• Study Design: A single-center retrospective study involving 113 patients.
• Methodology: Comparison of DNF-calculated velocities with TCD-measured velocities across seven major cerebral arteries.
• Data Analysis: Patient-specific inflow boundary conditions were defined using TCD measurements to ensure physiologically consistent comparisons.

Key Findings:

• Statistically significant positive correlation between DNF-calculated velocities and TCD measurements (Pearson’s r = 0.74, p < 0.0001), indicating a strong relationship between the two methods.
• DNF provides a non-invasive alternative for comprehensive cerebrovascular assessment.

Interpretation:

DNF overcomes limitations associated with conventional TCD by integrating anatomical context with hemodynamic assessment.

Limitations:

• Study conducted at a single center, which may limit generalizability.
• Retrospective design may introduce biases.

Conclusion:

DNF offers a robust method for assessing cerebral hemodynamics.