An uncommon cause of high pulse pressure variation (PPV) - Summary - MDSpire

An uncommon cause of high pulse pressure variation (PPV)

  • By

  • Stefano Skurzak

  • Manuela Crucitti

  • Valentina Ballerini

  • Chiara Stratta

  • July 13, 2026

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Objective:

To discuss elevated pulse pressure variation (PPV) in patients with atrioventricular dissociation due to complete AV block and independent ventricular pacing.

Approach:
  • Physiological Insights: High PPV indicates issues in heart-lung interactions and is a reliable indicator of fluid responsiveness under specific conditions.
  • Mechanism of PPV: In cases of complete AV block, PPV arises from uncoordinated atrial and ventricular contractions, affecting stroke volume based on the PR interval.
Key Findings:
  • High PPV can signal physiological disturbances in heart-lung interactions.
  • Atrioventricular dissociation can lead to significant fluctuations in PPV.
Interpretation:

Large fluctuations in plethysmographic and arterial waveforms in patients with ventricular pacing should be interpreted with caution.

Limitations:
  • Variability in the prevalence of single-chamber pacemakers across different countries.
Conclusion:

Understanding the mechanisms behind elevated PPV in specific pacing scenarios is important.

Sources:

Original Source(s)

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