A gender-based investigation of risk factors for infectious complications after percutaneous nephrolithotomy for kidney stones: insight for personalized management - Summary - MDSpire
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A gender-based investigation of risk factors for infectious complications after percutaneous nephrolithotomy for kidney stones: insight for personalized management
To investigate gender-related predictors of infectious complications following PCNL in patients with kidney stones, highlighting the significance of tailored management strategies.
Key Findings:
Female patients exhibited a higher risk of developing stone-related infections and urosepsis compared to males, necessitating gender-specific management approaches.
Postoperative fever occurred in 21.0% to 39.8% of cases and is a predictor of severe infectious outcomes, underscoring the need for vigilant monitoring.
Identified clinical and procedural factors influencing infection risk include positive preoperative bladder urine culture, diabetes, and larger stone burden, which should be considered in preoperative assessments.
Interpretation:
The study highlights the need for gender-specific risk stratification in managing patients undergoing PCNL, as females are at a higher risk for infectious complications, which could inform tailored management strategies.
Limitations:
Retrospective design may introduce selection bias and limit causal inferences.
Limited generalizability due to single-center study, suggesting the need for multicenter validation.
Conclusion:
Understanding gender-specific risk factors can enhance personalized management strategies for patients undergoing PCNL, potentially improving outcomes and informing future clinical guidelines.
by Federica Passarelli, Ludovico Maria Basadonna, Fabio Ciamarra, Gianpaolo Lucignani, Francesco Ripa, Stefano Paolo Zanetti, Elisa De Lorenzis, Giancarlo Albo, Emanuele Montanari, Luca Boeri
