Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus - Summary - MDSpire

Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus

  • By

  • Rachel MacCann

  • Junhui Li

  • Alejandro Abner Garcia Leon

  • Riya Negi

  • Dana Alalwan

  • Willard Tinago

  • Padraig McGettrick

  • Aoife G Cotter

  • Alan Landay

  • Caroline Sabin

  • Paul W O’Toole

  • Patrick W G Mallon

  • for the Understanding the Pathology of Comorbid Disease in HIV-Infected Individuals (HIV UPBEAT) Study Group

  • Padraig McGettrick

  • Elena Alvarez Barco

  • Willard Tinago

  • Alejandro Garcia Leon

  • Aoife McDermott

  • Tara McGinty

  • Aoife G Cotter

  • Alan Macken

  • Patrick W G Mallon

  • Eoin Kavanagh

  • Geraldine McCarthy

  • Gerard Sheehan

  • John Lambert

  • William Powderly

  • Juliet Compston

  • Caroline Sabin

  • January 24, 2025

  • 0 min

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Objective:

To investigate the interactions between gut microbiome compositions and systemic inflammatory responses in relation to subclinical cardiovascular disease (CVD) outcomes in individuals with HIV, highlighting the importance of understanding these relationships for improving cardiovascular health.

Key Findings:
  • Individuals with HIV had higher rates of hypercholesterolemia (P < .025).
  • Gut microbiome β-diversity significantly differed by HIV status (P < .01).
  • Certain gut bacteria correlated with lower plaque burden, while others correlated with higher plaque burden and fat intake.
  • Depleted Bacteroides spp and Alistepes spp were linked to elevated inflammatory biomarkers (P < .05).
Interpretation:

Gut microbiota differences in people with HIV are associated with subclinical CVD, diet, and inflammation, indicating the microbiome's role in cardiovascular risk and suggesting potential areas for clinical intervention.

Limitations:
  • The study's observational design limits causal inferences, making it difficult to establish direct relationships.
  • The sample size may not fully represent the broader population, potentially affecting the generalizability of the findings.
Conclusion:

Understanding gut microbiome interactions with inflammation in HIV could provide insights into cardiovascular risk and inform preventive strategies, such as dietary modifications and targeted microbiome therapies.

Original Source(s)

Associations Between the Gut Microbiome, Inflammation, and Cardiovascular Profiles in People With Human Immunodeficiency Virus

  • by Rachel MacCann, Junhui Li, Alejandro Abner Garcia Leon, Riya Negi, Dana Alalwan, Willard Tinago, Padraig McGettrick, Aoife G Cotter, Alan Landay, Caroline Sabin, Paul W O’Toole, Patrick W G Mallon, for the Understanding the Pathology of Comorbid Disease in HIV-Infected Individuals (HIV UPBEAT) Study Group, Padraig McGettrick, Elena Alvarez Barco, Willard Tinago, Alejandro Garcia Leon, Aoife McDermott, Tara McGinty, Aoife G Cotter, Alan Macken, Patrick W G Mallon, Eoin Kavanagh, Geraldine McCarthy, Gerard Sheehan, John Lambert, William Powderly, Juliet Compston, Caroline Sabin

  • January 24, 2025

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