Objective:

To synthesize current knowledge on the ovarian immune microenvironment's role in oocyte development, follicular maturation, and its implications in ovarian aging and premature ovarian insufficiency (POI).

Approach:

Key Findings:

• Dysregulation of the ovarian immune microenvironment is a core driver of functional decline.
• Physiological ovarian aging is characterized by chronic low-grade inflammation and immune alterations similar to those observed in POI.
• Over 70% of POI cases are idiopathic, indicating a need for understanding common regulatory mechanisms.

Interpretation:

Limitations:

• The review does not provide new experimental data but synthesizes existing knowledge.
• The complexity of immune interactions in the ovarian microenvironment may not be fully captured.

Conclusion:

Attribution Notice

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