Objective:

To explore the effectiveness and safety of topical hyaluronic acid dressings in promoting skin recovery and reducing inflammatory reactions after fractional laser surgery, highlighting its potential clinical implications.

Key Findings:

• HA group had significantly shorter times to erythema disappearance and scab shedding compared to RC group (p < 0.05), indicating faster recovery.
• Lower serum IL-6 and TNF-α levels in HA group at postoperative days 7 and 14 (p < 0.05), suggesting reduced inflammation.
• On day 14, HA group showed lower TEWL and higher skin moisture content (p < 0.05), indicating improved skin barrier function.
• MI, EI, and VAS scores were notably lower in HA group (p < 0.05), reflecting better patient-reported outcomes.
• Topical hyaluronic acid was confirmed as an independent favorable factor for skin recovery, emphasizing its therapeutic potential.

Interpretation:

The use of topical hyaluronic acid significantly enhances skin recovery and reduces inflammatory responses after fractional laser surgery, potentially through its moisturizing and anti-inflammatory properties.

Limitations:

• Retrospective design may introduce bias, affecting the reliability of the findings.
• Limited generalizability due to single-center study.
• Lack of long-term follow-up data.

Conclusion:

Topical hyaluronic acid dressings combined with routine care improve skin recovery and mitigate inflammation post-fractional laser surgery, suggesting their clinical utility in postoperative management and warranting further research.