Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk in U.S. Adults: Findings from a NHANES Cross-Sectional Analysis - Summary - MDSpire

Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk in U.S. Adults: Findings from a NHANES Cross-Sectional Analysis

  • By

  • Yuanze Du

  • Wenxue Sun

  • Jiaqi Zhang

  • Jinfeng Wang

  • Kai Deng

  • Xiaowei Qiao

  • Jie Zhang

  • Xiaofang Zhang

  • Yueyuan Li

  • Xinyu Zhang

  • Xin Yang

  • Fangyu Cheng

  • Zongshuai Wang

  • Chunping Wang

  • March 4, 2026

  • 0 min

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Objective:

To investigate the relationship between different stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome and all-cause mortality in U.S. adults, addressing a critical gap in existing research.

Key Findings:
  • Higher CKM stages are strongly associated with increased all-cause mortality risk, with specific data indicating a significant correlation.
  • Approximately 90.8% of U.S. adults were affected by CKM between 2011 and 2022, highlighting the widespread nature of the syndrome.
  • 15% of U.S. adults have advanced CKD (stage 3 or 4), underscoring the severity of the issue.
Interpretation:

The study highlights the significant impact of CKM syndrome stages on mortality risk, emphasizing the need for integrated management of these interconnected health conditions to inform public health policy.

Limitations:
  • Cross-sectional design limits causal inference, making it difficult to establish direct cause-and-effect relationships.
  • Potential biases in self-reported data may affect the accuracy of the findings.
Conclusion:

Understanding the relationship between CKM syndrome stages and mortality can inform urgent public health strategies to reduce the burden of these conditions in the U.S.

Original Source(s)

Linking Stages of Cardiovascular-Kidney-Metabolic Syndrome to All-Cause Mortality Risk in U.S. Adults: Findings from a NHANES Cross-Sectional Analysis

  • by Yuanze Du, Wenxue Sun, Jiaqi Zhang, Jinfeng Wang, Kai Deng, Xiaowei Qiao, Jie Zhang, Xiaofang Zhang, Yueyuan Li, Xinyu Zhang, Xin Yang, Fangyu Cheng, Zongshuai Wang, Chunping Wang

  • March 4, 2026

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