Visceral fat area and visceral-to-subcutaneous fat ratio are more strongly associated with residual cholesterol than conventional anthropometric indices in adults with type 2 diabetes - Summary - MDSpire
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Visceral fat area and visceral-to-subcutaneous fat ratio are more strongly associated with residual cholesterol than conventional anthropometric indices in adults with type 2 diabetes
To compare associations of general and central adiposity indices with residual cholesterol (RC) in adults with type 2 diabetes (T2D), emphasizing the significance of these comparisons for cardiovascular risk assessment.
Key Findings:
Higher RC was associated with male sex, current smoking, and increased adiposity indices.
After adjustment, only VFA and VFA/SFA remained independently related to RC, with β coefficients and 95% confidence intervals provided.
The highest VFA quartile was linked to 0.383 mmol/L higher RC; the highest VFA/SFA quartile to 0.562 mmol/L higher RC, with confidence intervals included.
A non-linear association was observed between VFA/SFA and RC, with a critical threshold around 0.72.
Interpretation:
Indices of visceral fat accumulation, particularly VFA and VFA/SFA, are more strongly associated with RC than traditional measures like BMI, WC, or WHtR, suggesting implications for clinical practice in risk stratification.
Limitations:
The study is cross-sectional, limiting causal inferences.
Data derived from a single center may affect generalizability.
Potential confounding factors not accounted for in the analysis.
Conclusion:
Detailed visceral adiposity assessment may enhance RC-related risk stratification beyond traditional measures.
