Pharmacokinetic-guided versus weight-guided coagulation factor replacement in hemophilia patients undergoing arthroplasty: a retrospective real-world study on perioperative bleeding risk and economic outcomes - Summary - MDSpire

Pharmacokinetic-guided versus weight-guided coagulation factor replacement in hemophilia patients undergoing arthroplasty: a retrospective real-world study on perioperative bleeding risk and economic outcomes

  • By

  • Shuxia Zhang

  • Yi Chen

  • Haojie Qin

  • Jing Chen

  • Chunrong Chen

  • Xuemei Wu

  • Min Chen

  • Jiajun Lin

  • Fenge Yang

  • Meijuan Huang

  • July 14, 2026

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Objective:

To compare the perioperative bleeding risk and economic outcomes of pharmacokinetic (PK)-guided versus weight-guided coagulation factor replacement regimens in hemophilia patients undergoing joint arthroplasty.

Approach:
  • Surgical Procedures: Seventeen patients underwent total knee or hip arthroplasty, and 16 underwent partial knee or hip arthroplasty.
Key Findings:
  • Postoperative quality of life scores showed significant improvement compared to preoperative baselines.
Interpretation:

PK-guided coagulation factor infusion regimens significantly reduced factor consumption and overall medical costs without a statistically significant increase in perioperative bleeding risk compared to weight-guided approaches.

Limitations:
  • Retrospective design may introduce bias.
  • Non-random assignment of patients to treatment groups after 2020.
Conclusion:

Further confirmation in larger prospective studies is warranted.

Original Source(s)

Pharmacokinetic-guided versus weight-guided coagulation factor replacement in hemophilia patients undergoing arthroplasty: a retrospective real-world study on perioperative bleeding risk and economic outcomes

  • by Shuxia Zhang, Yi Chen, Haojie Qin, Jing Chen, Chunrong Chen, Xuemei Wu, Min Chen, Jiajun Lin, Fenge Yang, Meijuan Huang

  • July 14, 2026

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