To analyze the clinical characteristics and prognosis of pregnancy-associated breast cancer (PABC), focusing on specific factors such as age at diagnosis and treatment outcomes, and to develop a nomogram for estimating disease-free survival (DFS).
Key Findings:
The incidence of PABC is rising, with a worse prognosis compared to non-PABC cases.
Patients diagnosed in late pregnancy or early postpartum have significantly worse outcomes.
Inadequate or excessive gestational weight gain may influence the prognosis of PABC.
Interpretation:
The study highlights the importance of monitoring gestational weight gain and its potential impact on the prognosis of pregnancy-associated breast cancer, suggesting that clinical guidelines should incorporate GWG monitoring.
Limitations:
The small sample size of 69 patients may limit generalizability, potentially affecting the applicability of the findings to broader populations.
The retrospective design may introduce bias in data collection, which could influence the study's conclusions.
Conclusion:
The developed nomogram can aid in predicting DFS in PABC patients, emphasizing the need for further research on gestational weight gain's role in breast cancer prognosis and its integration into clinical practice.
