Objective:

To evaluate the association between cardiovascular and metabolic comorbidities and sepsis severity in ICU patients, and to characterize the inflammatory profile using specific biomarkers (PCT, IL-6, IL-10, TNF-α).

Key Findings:

• Sepsis is associated with significant mortality and long-term complications, particularly in patients with pre-existing cardiovascular conditions, highlighting the need for targeted interventions.
• Inflammatory markers play a crucial role in predicting sepsis severity and outcomes, suggesting their potential use in clinical decision-making.
• The study highlights the need for risk stratification in sepsis patients with cardiovascular and metabolic comorbidities to improve management strategies.

Interpretation:

The presence of cardiovascular and metabolic comorbidities significantly impacts the severity of sepsis and may worsen patient outcomes, emphasizing the importance of monitoring inflammatory markers to guide treatment decisions.

Limitations:

• Retrospective design may introduce bias.
• Single-center study limits generalizability.
• Sample size may not fully represent the broader population.
• Potential confounding factors such as age, sex, and other comorbidities were not fully controlled.

Conclusion:

The study underscores the critical role of cardiovascular and metabolic comorbidities in sepsis severity and outcomes, suggesting that tailored management strategies, such as early intervention and monitoring of inflammatory markers, may be necessary for affected patients.