Objective:

To clarify whether specific tissue adhesive products are associated with higher rates of contact dermatitis in patients undergoing laparoscopic surgery.

Approach:

• Study Design: A single-center, intra-patient, randomized controlled trial comparing Dermabond™ (DB) and LiquiBand® (LB) in patients undergoing laparoscopic surgery.
• Participants: Adult patients (≥ 18 years) undergoing elective laparoscopic or robotic abdominal surgery were included, while those with known allergies to skin glue or unable to complete follow-up were excluded.
• Randomization: Each participant served as their own control, with DB applied to one side of the abdomen and LB to the other, randomly assigned by day of the month.
• Outcomes: Primary outcome was the proportion of patients with contact dermatitis within 6 weeks postoperative; secondary outcomes included wound dehiscence and surgical site infection.
• Statistical Analysis: Intention to treat analysis and univariate analysis were performed, with the primary outcome analyzed using an exact McNemar’s test.

Key Findings:

• A total of 180 patients underwent laparoscopic or robotic abdominal surgery with both adhesives applied.
• Female patients were more likely to have a reaction to any glue (15% vs. 2%, p = 0.013).

Interpretation:

The study aims to provide data on the rates of contact dermatitis associated with different tissue adhesives.

Limitations:

• The study was conducted at a single center, which may limit generalizability.
• No prior studies directly compared DB and LB regarding contact dermatitis rates.

Conclusion:

The study seeks to determine if LB is associated with a higher rate of contact dermatitis compared to DB.